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weekly question 14/6/2026

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A term infant is born with a congenital chylothorax. The neonatal team places a chest tube and begins an octreotide infusion. The parents inquire about the safety of this medication. The most common clinical adverse event in infants receiving an octreotide infusion is:

a Intraventricular hemorrhage

b Necrotizing enterocolitis

c Seizures

d Hypotension requiring vasopressors

e Symptomatic hypoglycemia
 
A term infant is born with a congenital chylothorax. The neonatal team places a chest tube and begins an octreotide infusion. The parents inquire about the safety of this medication. The most common clinical adverse event in infants receiving an octreotide infusion is:

a Intraventricular hemorrhage

b Necrotizing enterocolitis

c Seizures

d Hypotension requiring vasopressors

e Symptomatic hypoglycemia
E
 
A term infant is born with a congenital chylothorax. The neonatal team places a chest tube and begins an octreotide infusion. The parents inquire about the safety of this medication. The most common clinical adverse event in infants receiving an octreotide infusion is:

a Intraventricular hemorrhage

b Necrotizing enterocolitis

c Seizures

d Hypotension requiring vasopressors

e Symptomatic hypoglycemia
B
 
A term infant is born with a congenital chylothorax. The neonatal team places a chest tube and begins an octreotide infusion. The parents inquire about the safety of this medication. The most common clinical adverse event in infants receiving an octreotide infusion is:

a Intraventricular hemorrhage

b Necrotizing enterocolitis

c Seizures

d Hypotension requiring vasopressors

e Symptomatic hypoglycemia
d
 
correct answer
d Hypotension requiring vasopressors

Octreotide has been used in a number of clinical conditions in infants. Most commonly chylothorax, hypoglycemia and gastrointestinal hemorrhage. A 2015 study of 428 infants over 15 years at 333 neonatal ICUs demonstrated that laboratory abnormalities were relatively common, particularly thrombocytopenia (47/1000 infant days), hyperkalemia (21/1000) and leukocytosis (20/1000). Hyper and hypoglycemia were rare. The most common clinical adverse event was hypotension requiring pressor support (12%). NEC complicated 2% of cases and death occurred in 3 %.
 
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